Calcium to help you Phosphorus Proportion, PTH, and you may Bone Fitness

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Prices because of the Ray Peat, PhD: “The brand new proportion of calcium supplements to phosphate is very important; this is exactly why dairy and you may cheddar are incredibly valuable for weight loss, and for preventing gaining weight. For people who aren’t extremely effective, reduced fat milk and you can mozzarella cheese function better, just like the body fat fat aren’t expected.”

“The meals large from inside the phosphate, relative to calcium supplements, was cereals, legumes, meat, and you will fish. Of numerous wishing food contain extra phosphate. Food having a higher, secure proportion away from calcium to help you phosphate are simply leaves, like kale, turnip greens, and beet vegetables, and several good fresh fruit, milk products, and you can mozzarella cheese.”

Br J Nutr

“100 % free unsaturated essential fatty acids turn on the stress hormonal, and you can cortisol reduces oxidation away from glucose and you may converts it to the fatty acids and triglycerides. Keeping cortisol and you can stress reasonable ‘s the chief thing. Keeping a leading ratio of calcium in order to phosphate helps to contradict the pressure metabolic process.” “Current publication is actually appearing that excess phosphate can increase inflammation, structure atrophy, calcification out of bloodstream, cancer, dementia, and you will, as a whole, the techniques from aging.”

2006 September;96(3):545-52. Higher phosphorus intakes exceptionally and you will adversely apply to California and you may bones k-calorie burning within the a dose-centered trend in match more youthful lady. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. Ca and you will P is actually both essential nutrients for bone as they are proven to apply to probably one of the most extremely important authorities out-of limbs metabolism, parathyroid hormones (PTH). Too substantial a beneficial P intake, typical off Western diet, might possibly be deleterious so you’re able to limbs from increased PTH secretion. Few regulated amount-reaction scientific studies are on the results away from higher P consumption inside the man. I analyzed this new quick-name outcomes of five P dosages towards Ca and bone metabolism in fourteen healthy female, 20-twenty eight yrs . old, who had been randomized so you can five managed analysis weeks; for this reason for each and every study subject supported because her own handle. P enhance dosage from 0 (placebo), 250, 750 otherwise 1500 milligrams was in fact taken, divided into three doses into the investigation go out. The dishes served was basically exactly the same during the for each and every research date and you will given 495 milligrams P and 250 mg Ca. The fresh P amounts impacted the brand new serum PTH (S-PTH) during the an amount-established trend (P=0.0005). There’s a reduction in serum ionized California attention merely in the the highest P dosage eros escort Springfield IL (P=0.004). Brand new marker away from bone development, bone-certain alkaline phosphatase, decreased (P=0.05) while the bone resorption marker, N-terminal telopeptide out of collagen sort of I, enhanced in reaction on P amounts (P=0.05). So it controlled amount-impulse study showed that P features a dose-built influence on S-PTH and increases PTH hormonal notably whenever California intake is actually reasonable. Excessively high P consumption negatively has an effect on bone metabolic process by the decreasing limbs formation and you will broadening bone resorption, since shown by the bones metabolic process indicators.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.